Technical Reference
Technical Documentation
Zetyra's documentation is designed as a technical whitepaper for statisticians and regulatory professionals. Each page covers the mathematical foundations, explicit assumptions, and references required for Statistical Analysis Plans (SAPs).
Built for Regulatory Rigor
Statisticians don't just want to know how to use a tool—they want to see the math that proves it works. Each documentation page includes formal mathematical equivalences, explicit assumptions with testable criteria, regulatory guidance citations, and validation benchmarks against industry-standard software.
CUPED & Covariate Adjustment
Theoretical foundation, statistical assumptions, and regulatory considerations for CUPED variance reduction.
Group Sequential Design
O'Brien-Fleming, Pocock, and spending functions. Interim analyses with rigorous Type I error control.
Bayesian Predictive Power
Predictive probability methods. Prior specification, MCMC convergence, and decision thresholds for clinical trials.