Statistical Design Software
Stop paying $1,000+ for clunky desktop software. Run Group Sequential designs, CUPED, and Bayesian simulations directly in your browser.
51
Validation tests against PASS & nQuery
30%
Sample size reduction with CUPED
$99
Per month vs $4,995/yr for nQuery
Figure 1
O'Brien-Fleming Stopping Boundaries
Parameters
Output matches gsDesign R package v3.6.0
Why Zetyra
Statistical engines built for the highest levels of scrutiny. Transparent, reproducible, and benchmarked against industry standards to support FDA- and EMA-ready trial design.
Eliminate “black box” calculations. Zetyra utilizes standardized R-backends for statistical legitimacy, providing full methodology transparency for your SAP.
Built for computational velocity. Run complex Monte Carlo simulations and adaptive design iterations at scale without legacy desktop latency.
Algorithms rigorously cross-validated against established standards, achieving numerical parity with industry-leading software.
Table 1
Validation Against Industry Standards
| Industry Standard | Parity Level | Guideline Alignment |
|---|---|---|
| Two-sample t-test (Satterthwaite) | Full Parity | Consistent with ICH E9 principles |
| GSD (O'Brien-Fleming) | Full Parity | Designed for FDA/EMA Stopping Rules |
| Bayesian Predictive Power | Optimized | Supports adaptive design frameworks |
Optimize trial efficiency with precise Group Sequential boundaries. Use O'Brien-Fleming or Pocock spending functions to calculate stopping rules without compromising Type I error (α). Zetyra ensures that the preservation of the family-wise error rate is mathematically sound and fully reproducible.
Calculators
From basic power analysis to advanced adaptive designs.
View All CalculatorsVariance reduction using pre-experiment data
Save ~30% on sample size — that's 3,000 fewer subjects on a 10K trial
Interim analyses with stopping boundaries
Stop failing trials early — save months of recruitment time
Predictive probability simulations
Know your trial's chances before investing resources
Two-sample t-test power analysis
Get answers in seconds — no PASS license needed
Resources
Technical validation for biostatisticians. Business case for decision makers.
Pricing
Start free. Upgrade when you need advanced features. Cancel anytime.
Competitor pricing
nQuery Pro: $4,995/yr
Zetyra Pro: $99/mo
Free
Pro
Recommended$29/mo for .edu
Team
5 seats included
We maintain an open-source validation suite with 51 automated tests against industry gold standards. Our GSD module matches the gsDesign R package within 0.005 z-score units. We also replicate published clinical trials (HPTN 083, HeartMate II) and validate CUPED/Bayesian calculations against analytical formulas. View our full validation suite at github.com/evidenceinthewild/zetyra-validation.
For Group Sequential designs, we use the industry-standard gsDesign R package directly in our backend. For CUPED and Bayesian simulations, we use custom Python implementations built on NumPy and SciPy, validated against published statistical methods and MCMC simulations.
Yes. Zetyra uses the same gsDesign R package that powers many FDA-approved clinical trial designs, and our calculations match industry-standard software. For regulatory submissions, we recommend including the exported PDF report (which lists all parameters and version numbers) alongside your Statistical Analysis Plan.
Yes. Pro users can export professional PDF reports that include all input parameters and results. We are also actively developing R script export for Group Sequential designs, allowing you to paste the exact generation code into your analysis plan.
We have a REST API available for Enterprise partners who need programmatic access to our calculators. Contact sales@zetyra.com if you need to integrate Zetyra into your internal workflow or run bulk calculations.
No. All plans are month-to-month. Cancel anytime with no questions asked.
Zetyra provides the same statistical accuracy (validated against both) at a fraction of the cost. PASS/nQuery offer broader legacy test coverage but require expensive desktop licenses ($1,295+/year). Zetyra focuses on modern clinical trial designs (GSD, CUPED), runs in your browser with no installation, and enables easy sharing—starting at $99/mo.
We treat your designs as confidential. All data is encrypted in transit (TLS 1.3) and at rest. Input parameters are processed in real-time and not stored unless you explicitly save a project. We never use your data to train models or share it with third parties.
Evidence Collective ($349/month) includes 5 team seats, everything in Pro, a shared project library, team commenting and review features, and priority email support. It's designed for biostatistics departments that need to collaborate on trial designs. Additional seats can be added for $49/month each.
Yes! Academic users with a .edu email get Evidence Pro for just $29/month—70% off the standard price. This applies to graduate students, postdocs, and faculty. Sign up with your .edu email to automatically receive the discount.
If you cancel your Pro subscription, you retain access until the end of your billing period. Afterwards, your account reverts to the free tier. Your saved projects remain in your account as read-only (you can view and export them, but not edit).